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Title   침윤성 유방암종에서 미세혈관의 변화와 림프절 전이와 상관관계 ( Correlation of Tumor Angiogenesis and Lymph Node Metastasis in Invasive Breast Carcinoma )
Publicationinfo   1993 Jan; 025(06): 920-928.
Key_word   Angiogenesis, Metastasis, Number of microvessel, Breast carcinoma, Relative
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Abstract   Angiogenesis is a process of generating new capillary blood vessels and leads to neovascularization, which is related to the growth of solid tumor and metastasis. A tumor must stimulate the growth of new capillary blood vessels for tumor itself to grow. Futhermore, the new blood vessels embedded in a tumor provide a gateway for tumor cells to enter the circulation and to metastasize to distant sites. To investigate how tumor angiogenesis correlate with metastases in breast carcinoma, we counted the number of microvesaels including venule, arteriole and capillaries(per x 200 field) within the tumor of 92 cases(47 with metastasis and 45 without). We have also analysed rela- tionship between lymph node meiastasis and other estabilished prognostic factors. The risk of metastasis is increased in propartion as a number of microvessel within tumor increases: relative risk of node metastasis in graup with highest number of microvessels(above 54/X200PF) is 87.75 fold compaired to group with lowest number of microvessels(under 36/X200PF) (p value <0.00l). This result support that the number of microvessels mostly composed of neovessels within tumor is strongly correlated with lymph nade metaetasis. This study also shows that group with larger tumor size and lower Blacks nuclear grade has a tendency to have high risk of metastasis, although statistically not significant. Patient's age, Bloam-Richardson grade and estrogen receptor status do not show significant association with node metastasis.
저 자   김영배(Young Bae Kim),황태숙(Tae Sook Hwang)